Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities

Withania somnifera (WS) (Dunal) or Ashwagandha is a well-known hypolipidemic herb and antioxidant. In this study, 75% ethanolic extract of WS attempted to evaluate the cardioprotective activity isoproterenol-induced cardiotoxicity in Triton WR 1339-induced hyperlipidemia. addition, phytochemical evaluation same extracts analyzed by gas chromatography–mass spectrometer (GC–MS). This study found that 7 days therapy with at 1000 mg/kg b.wt. reduced cholesterol 76%, low-density lipoprotein (LDL) 71%, TAG 12% (P < 0.05). Furthermore, it can significantly reduce LDL levels Similarly, use 50 showed effect against cardiac toxic rats. The antioxidants glutathione, glutathione peroxidase, catalase are increased 0.05), whereas release indicators heart tissue 30-day treatment also triacylglycerol isoprenaline-induced cardiotoxic GC–MS analysis methanol fraction 70% presence higher concentrations fatty acids. conclusion, activities diseased animals induced isoproterenol 1339.